orphenadrine increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
aclidinium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
acrivastine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and alfentanil both increase sedation. Use Caution/Monitor.
alprazolam and orphenadrine both increase sedation. Use Caution/Monitor.
amisulpride and orphenadrine both increase sedation. Use Caution/Monitor.
amitriptyline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and amitriptyline both increase sedation. Use Caution/Monitor.
amobarbital and orphenadrine both increase sedation. Use Caution/Monitor.
amoxapine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and amoxapine both increase sedation. Use Caution/Monitor.
orphenadrine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
anticholinergic/sedative combos and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and apomorphine both increase sedation. Use Caution/Monitor.
orphenadrine and aripiprazole both increase sedation. Use Caution/Monitor.
asenapine and orphenadrine both increase sedation. Use Caution/Monitor.
asenapine transdermal and orphenadrine both increase sedation. Use Caution/Monitor.
atracurium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
atropine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
atropine IV/IM and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.avapritinib and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
azelastine and orphenadrine both increase sedation. Use Caution/Monitor.
baclofen and orphenadrine both increase sedation. Use Caution/Monitor.
belladonna alkaloids and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
belladonna and opium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and belladonna and opium both increase sedation. Use Caution/Monitor.
orphenadrine and benperidol both increase sedation. Use Caution/Monitor.
orphenadrine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
benztropine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use.
bethanechol increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
brexanolone, orphenadrine.Either increases toxicity of the other by sedation. Use Caution/Monitor.
brexpiprazole and orphenadrine both increase sedation. Use Caution/Monitor.
brimonidine and orphenadrine both increase sedation. Use Caution/Monitor.
brivaracetam and orphenadrine both increase sedation. Use Caution/Monitor.
brompheniramine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and buprenorphine both increase sedation. Use Caution/Monitor.
orphenadrine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
buprenorphine, long-acting injection increases effects of orphenadrine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and increase risk for respiratory depression. Monitor for signs of respiratory depression that may be greater than otherwise expected and decrease muscle relaxant dosage as necessary.
butabarbital and orphenadrine both increase sedation. Use Caution/Monitor.
butalbital and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and butorphanol both increase sedation. Use Caution/Monitor.
carbachol increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
carbinoxamine and orphenadrine both increase sedation. Use Caution/Monitor.
cariprazine and orphenadrine both increase sedation. Use Caution/Monitor.
carisoprodol and orphenadrine both increase sedation. Use Caution/Monitor.
cevimeline increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
chloral hydrate and orphenadrine both increase sedation. Use Caution/Monitor.
chlordiazepoxide and orphenadrine both increase sedation. Use Caution/Monitor.
chlorpheniramine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and chlorpromazine both increase sedation. Use Caution/Monitor.
chlorzoxazone and orphenadrine both increase sedation. Use Caution/Monitor.
cinnarizine and orphenadrine both increase sedation. Use Caution/Monitor.
cisatracurium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
clemastine and orphenadrine both increase sedation. Use Caution/Monitor.
clomipramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and clomipramine both increase sedation. Use Caution/Monitor.
clonazepam and orphenadrine both increase sedation. Use Caution/Monitor.
clorazepate and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and clozapine both increase sedation. Use Caution/Monitor.
orphenadrine and codeine both increase sedation. Use Caution/Monitor.
cyclizine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclizine and orphenadrine both increase sedation. Use Caution/Monitor.
cyclobenzaprine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprine and orphenadrine both increase sedation. Use Caution/Monitor.
cyproheptadine and orphenadrine both increase sedation. Use Caution/Monitor.
dantrolene and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
darifenacin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine increases effects of daxibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
desipramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and desipramine both increase sedation. Use Caution/Monitor.
dexchlorpheniramine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dexmedetomidine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and dextromoramide both increase sedation. Use Caution/Monitor.
orphenadrine and diamorphine both increase sedation. Use Caution/Monitor.
diazepam and orphenadrine both increase sedation. Use Caution/Monitor.
dicyclomine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
difelikefalin and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and difenoxin hcl both increase sedation. Use Caution/Monitor.
dimenhydrinate and orphenadrine both increase sedation. Use Caution/Monitor.
diphenhydramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
orphenadrine and dipipanone both increase sedation. Use Caution/Monitor.
donepezil increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and dosulepin both increase sedation. Use Caution/Monitor.
doxepin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and doxepin both increase sedation. Use Caution/Monitor.
doxylamine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and droperidol both increase sedation. Use Caution/Monitor.
echothiophate iodide increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
esketamine intranasal, orphenadrine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
estazolam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and ethanol both increase sedation. Use Caution/Monitor.
etomidate and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fesoterodine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Adjust finererone dosage as needed.
flavoxate and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.
orphenadrine and fluphenazine both increase sedation. Use Caution/Monitor.
flurazepam and orphenadrine both increase sedation. Use Caution/Monitor.
galantamine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and ganaxolone both increase sedation. Use Caution/Monitor.
glycopyrrolate and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
glycopyrrolate inhaled and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and haloperidol both increase sedation. Use Caution/Monitor.
homatropine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
huperzine A increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and hydromorphone both increase sedation. Use Caution/Monitor.
hydroxyzine and orphenadrine both increase sedation. Use Caution/Monitor.
hyoscyamine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
hyoscyamine spray and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and iloperidone both increase sedation. Use Caution/Monitor.
imipramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and imipramine both increase sedation. Use Caution/Monitor.
orphenadrine increases effects of incobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
ipratropium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
orphenadrine increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor when coadministered with weak CYP3A4 inhibitors .
ketamine and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
orphenadrine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.
orphenadrine increases effects of letibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
levetiracetam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and levorphanol both increase sedation. Use Caution/Monitor.
lofepramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and lofepramine both increase sedation. Use Caution/Monitor.
orphenadrine and lofexidine both increase sedation. Use Caution/Monitor.
orphenadrine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.
loprazolam and orphenadrine both increase sedation. Use Caution/Monitor.
lorazepam and orphenadrine both increase sedation. Use Caution/Monitor.
lormetazepam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and loxapine inhaled both increase sedation. Use Caution/Monitor.
lurasidone, orphenadrine.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
maprotiline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and maprotiline both increase sedation. Use Caution/Monitor.
orphenadrine and marijuana both increase sedation. Use Caution/Monitor.
orphenadrine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose.
meclizine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and melatonin both increase sedation. Use Caution/Monitor.
orphenadrine and meperidine both increase sedation. Use Caution/Monitor.
orphenadrine and meprobamate both increase sedation. Use Caution/Monitor.
metaxalone and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and methadone both increase sedation. Use Caution/Monitor.
methocarbamol and orphenadrine both increase sedation. Use Caution/Monitor.
methscopolamine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
midazolam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.midazolam intranasal, orphenadrine.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
orphenadrine and mirtazapine both increase sedation. Use Caution/Monitor.
orphenadrine and morphine both increase sedation. Use Caution/Monitor.
orphenadrine and motherwort both increase sedation. Use Caution/Monitor.
orphenadrine and moxonidine both increase sedation. Use Caution/Monitor.
orphenadrine and nabilone both increase sedation. Use Caution/Monitor.
orphenadrine and nalbuphine both increase sedation. Use Caution/Monitor.
neostigmine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nortriptyline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and nortriptyline both increase sedation. Use Caution/Monitor.
orphenadrine and olanzapine both increase sedation. Use Caution/Monitor.
oliceridine, orphenadrine.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.orphenadrine increases toxicity of oliceridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.
orphenadrine increases effects of onabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
orphenadrine and opium tincture both increase sedation. Use Caution/Monitor.
oxazepam and orphenadrine both increase sedation. Use Caution/Monitor.
oxybutynin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
oxybutynin topical and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
oxybutynin transdermal and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and oxycodone both increase sedation. Use Caution/Monitor.
orphenadrine and oxymorphone both increase sedation. Use Caution/Monitor.
orphenadrine and paliperidone both increase sedation. Use Caution/Monitor.
pancuronium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and papaveretum both increase sedation. Use Caution/Monitor.
orphenadrine and papaverine both increase sedation. Use Caution/Monitor.
orphenadrine and pentazocine both increase sedation. Use Caution/Monitor.
pentobarbital and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and perphenazine both increase sedation. Use Caution/Monitor.
phenobarbital and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
orphenadrine and pholcodine both increase sedation. Use Caution/Monitor.
physostigmine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pilocarpine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and pimozide both increase sedation. Use Caution/Monitor.
orphenadrine increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
pralidoxime and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
primidone and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and prochlorperazine both increase sedation. Use Caution/Monitor.
promethazine and orphenadrine both increase sedation. Use Caution/Monitor.
propantheline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
propofol and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and protriptyline both increase sedation. Use Caution/Monitor.
pyridostigmine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
quazepam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and quetiapine both increase sedation. Use Caution/Monitor.
orphenadrine and ramelteon both increase sedation. Use Caution/Monitor.
rapacuronium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
remimazolam, orphenadrine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
orphenadrine increases effects of rimabotulinumtoxinB by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
orphenadrine and risperidone both increase sedation. Use Caution/Monitor.
rocuronium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
scopolamine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and scullcap both increase sedation. Use Caution/Monitor.
secobarbital and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and shepherd's purse both increase sedation. Use Caution/Monitor.
solifenacin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
stiripentol, orphenadrine.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
succinylcholine increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and sufentanil both increase sedation. Use Caution/Monitor.
orphenadrine and tapentadol both increase sedation. Use Caution/Monitor.
orphenadrine will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
temazepam and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and thioridazine both increase sedation. Use Caution/Monitor.
orphenadrine and thiothixene both increase sedation. Use Caution/Monitor.
orphenadrine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
tiotropium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
tolterodine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
orphenadrine and tramadol both increase sedation. Use Caution/Monitor.
trazodone and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and trazodone both increase sedation. Use Caution/Monitor.
triazolam and orphenadrine both increase sedation. Use Caution/Monitor.
triclofos and orphenadrine both increase sedation. Use Caution/Monitor.
orphenadrine and trifluoperazine both increase sedation. Use Caution/Monitor.
trihexyphenidyl and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.
trimipramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and trimipramine both increase sedation. Use Caution/Monitor.
trospium chloride and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
vecuronium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
orphenadrine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
orphenadrine and ziconotide both increase sedation. Use Caution/Monitor.
orphenadrine and ziprasidone both increase sedation. Use Caution/Monitor.
orphenadrine and zotepine both increase sedation. Use Caution/Monitor.
